Nonparametric Procedures for Finding Minimum Effective Dose in a One-Way Layout
نویسندگان
چکیده
منابع مشابه
Nonparametric identification of the minimum effective dose.
We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonp...
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This paper considers the extension of the dose finding problem in a one-way layout setting to the case of several groups, in which the main goal is to identify the minimum effective dose (MED) of each group simultaneously. We propose two nonparametric procedures using the respective pairwise- and Helmert-type two-sample Mann-Whitney statistics, which are applied in a step-down testing scheme fo...
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For the estimation and testing of contrasts in two-way layout, some optimum nonparametric procedures based on Chernoff-Savage [2] type of rank order statistics are considered here. The asymptotic properties of the proposed methods are studied and compared with those of the least square method.
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The problem of identifying the lowest dose level for which the mean response differs from that at the zero dose level is considered. A general framework for stepwise testing procedures that use contrasts among the dose level means is proposed. Using this framework, several new procedures are derived. These and some existing procedures, including that of Williams (1971, Biometrics 27, 103-117; 1...
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ژورنال
عنوان ژورنال: Communications for Statistical Applications and Methods
سال: 2002
ISSN: 2287-7843
DOI: 10.5351/ckss.2002.9.3.693